Tag Archives: Mild cognitive impairment

Overeating May Double Risk of Memory Loss

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By Steven Reinberg – HealthDay Reporter

Too many calories could lead to early signs of Alzheimer’s, preliminary research suggests.

Overeating May Double Risk of Memory LossOlder people who eat too much are at risk for memory impairment, a new study contends.

People 70 and older who eat between 2,100 and 6,000 calories a day may be at double the risk of these deficits in memory, which can be an early sign of Alzheimer’s disease, the study authors said.

“Excessive daily caloric consumption may not be brain-health friendly,” said lead researcher Dr. Yonas Geda, an associate professor of neurology and psychiatry at the Mayo Clinic in Scottsdale, Ariz.

“It may sound like a cliche, but we need to be mindful of our daily caloric consumption,” he said. “The bottom line is that eating in moderation, not in excess amount, may be good for your brain.”

The results of the study are due to be presented in April at the annual meeting of the American Academy of Neurology, in New Orleans. The data and conclusions should be viewed as preliminary until published in a peer-reviewed journal.

For the study, investigators collected data on more than 1,200 people, aged 70 to 89, living in Olmsted County, Minn. Among these people, 163 had been diagnosed with the memory deficits known as “mild cognitive impairment.”

Each person told the researchers how much they ate. One-third ate between 600 and 1,525 calories a day, one-third between 1,526 and 2,142 calories a day, and one-third ate between 2,143 and 6,000 calories a day.

Among those who ate the most, the odds of being diagnosed with the impaired-memory disorder was more than twice that of those who ate the least, the researchers found.

There was no significant increase in risk for memory problems among those in the middle group, the researchers added.

These findings remained the same after taking into account a history of stroke, diabetes, education and other risk factors for memory loss.

“We also looked at BMI and obesity,” Geda said. BMI, or body mass index, is a measurement based on height and weight. “But there was no significant difference between the normal [participants] and mild cognitive impairment when it comes to these two variables,” he said.

Why overeating affects the brain isn’t clear, but “excessive caloric intake may lead to oxidative damage leading to structural changes in the brain,” Geda suggested.

Commenting on the study, Dr. Neelum Aggarwal, an associate professor of neurological sciences at Rush University in Chicago, said that “as the population of the U.S. is aging at a rapid rate, in addition to becoming increasingly obese, physicians are being asked by their elderly patients about their risk for various diseases, specifically cognitive [mental] decline and dementia.”

These findings allow doctors to start the discussion about the links between common healthy living practices — eating a nutritious diet, limiting sugar — to overall brain function, he said.

“This study furthers the discussion of what the possible mechanisms are for the development of cognitive decline and offers strategies for disease prevention through nutrition and caloric restriction,” Aggarwal said.

Another expert, David Loewenstein, a professor of psychiatry and behavioral sciences at the University of Miami Miller School of Medicine, said that “this makes a lot of sense because increased caloric intake is associated with obesity and metabolic syndrome, so it is not at all surprising that increased calories are associated with increased cognitive impairment.” Metabolic syndrome is a group of risk factors linked to heart disease and other health problems.

“This study suggests that anything that’s good for the heart — like decreased calories — is good for the brain,” Loewenstein added.

While the study found an association between overeating and memory impairment, it did not prove a cause-and-effect relationship.

Source: http://consumer.healthday.com/Article.asp?AID=661692

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New Alzheimer’s Criteria Would Change Diagnosis for Millions

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By: Rachael Rettner, MyHealthNewsDaily Staff Writer

New Alzheimer's Criteria Would Change Diagnosis for MillionsAlmost everyone currently diagnosed with a mild form of Alzheimer’s disease would be downgraded to not having the condition, if new proposed criteria for the diagnosis of cognitive problems were applied, a new study shows.

Instead, people diagnosed as having “very mild” and “mild” Alzheimer’s disease would be reclassified as having mild cognitive impairment (MCI), which is currently recognized as an intermittent stage between the normal loss of mental function that comes with age and the development of dementia.

The new criteria broaden the definition of mild cognitive impairment, and this will cause confusion when doctors try to diagnose MCI and Alzheimer’s, said study researcher Dr. John Morris, a professor of neurology at Washington University School of Medicine in St. Louis.

Moreover, the new criteria highlight the fallacy of thinking about MCI and Alzheimer’s as different entities, Morris said.

“[The] idea that there is an MCI stage, distinct from very early Alzheimer’s disease, is artificial,” Morris said. “It really is the same disease process.”

Instead of widening the criteria so more people are diagnosed with MCI, researchers should do the opposite — try to figure how to winnow down the group of patients with MCI to find those who will go on to develop Alzheimer’s disease, Morris said. In fact, if a patient’s memory and thinking troubles are due to early Alzheimer’s, and not due to depression or medication use, “We can just call it very early Alzheimer’s disease. There’s no need to have this distinction,” Morris said.

The report is published online today (Feb. 6) in the Archives of Neurology.

Alzheimer’s Continuum

Previously, mild cognitive impairment was defined as a decline in cognitive function — which could include memory and language problems — that do not interfere with everyday activities.

But the new criteria, proposed by the National Institute on Aging and the Alzheimer’s Association, state that people with MCI have “independence in functional activities.”

This could mean that, as long as a person can do everyday activities by themselves, they would be classified as having MCI, even if they had mild problems with activities such as shopping, paying bills and cooking, Morris said. (In fact, having mild problems with such activities is a criterion for dementia, Morris said.)

To assess what the impact of the new criteria would be on patients diagnosed with Alzheimer’s disease, Morris analyzed information from 17,535 people who had been classified as having normal cognition, MCI or Alzheimer’s disease. Participants were classified based on how well they could function performing a variety of activities, including preparing meals and taking mediation.

The results showed 99.8 percent of patients currently diagnosed with very mild Alzheimer’s disease, and 92.7 percent of those diagnosed with mild Alzheimer’s disease, would be reclassified as having MCI based on the revised criteria.

Considering about 2.5 million people have very mild Alzheimer’s disease, the findings suggest that, very roughly, about 2.2 million people could be reclassified as having MCI (although this calculation is speculative), Morris said.

Need for Biomarkers

William Thies, chief medical and scientific officer at the Alzheimer’s Association, said the proposed criteria for MCI are less than a year old, and experts will likely continue to discuss and tweak them in the years to come.

“We are really now working on trying to identify exactly where people will fit in the continuum of Alzheimer’s disease,” Thies said.

Thies agreed the disease is a continuous process, and said you could likely not tell the difference between someone with the most severe case of MCI and someone with the mildest case of Alzheimer’s disease.

But Thies said he does not think the new criteria will create much confusion. They are intended to be used by experts in the field, some of whom have already been thinking of MCI in the manner described by the new criteria. And others who are very conservative when it comes to diagnosing people with Alzheimer’s disease likely won’t change their ways, he said.

Thies also said the field should move toward identifying which patients with MCI are actually in the early stages of Alzheimer’s disease. This could be done once there are well defined biomarkers for the condition, Thies said.

While the field is moving toward this goal, it will likely be a while before biomarkers are routinely used by doctors to diagnose patients, he said.

Pass it on: Identification of biomarkers for Alzheimer’s disease will make it easier to diagnosis the condition in its early stages.

Source: http://www.myhealthnewsdaily.com/2204-alzhimers-disease-criteria-mild-cognitive-impairment.html

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