How Regular Exercise Can Improve Mental Health and Brain Function

From the University of California – Davis Health System

The Effects of Exercise on the BrainRecent study from the UC Davis Health System finds that people who exercise tend to have better mental health, memory and cognitive abilities.

Regular intense exercise increases levels of two common neurotransmitters, glutamate and GABA, which are responsible for chemical messaging in the brain.

Published in this week’s issue of The Journal of Neuroscience, the finding offers new insights into brain metabolism and why exercise could become an important part of treating depression and other neuropsychiatric disorders linked with deficiencies in neurotransmitters, which drive communications between the brain cells that regulate physical and emotional health.

“Major depressive disorder is often characterized by depleted glutamate and GABA, which return to normal when mental health is restored,” said study lead author Richard Maddock, professor in the Department of Psychiatry and Behavioral Sciences. “Our study shows that exercise activates the metabolic pathway that replenishes these neurotransmitters.”

The research also helps solve a persistent question about the brain, an energy-intensive organ that consumes a lot of fuel in the form of glucose and other carbohydrates during exercise. What does it do with that extra fuel?

“From a metabolic standpoint, vigorous exercise is the most demanding activity the brain encounters, much more intense than calculus or chess, but nobody knows what happens with all that energy,” Maddock said. “Apparently, one of the things it’s doing is making more neurotransmitters.”

The striking change in how the brain uses fuel during exercise has largely been overlooked in brain health research. While the new findings account for a small part of the brain’s energy consumption during exercise, they are an important step toward understanding the complexity of brain metabolism. The research also hints at the negative impact sedentary lifestyles might have on brain function, along with the role the brain might play in athletic endurance.

“It is not clear what causes people to ‘hit the wall’ or get suddenly fatigued when exercising,” Maddock said. “We often think of this point in terms of muscles being depleted of oxygen and energy molecules. But part of it may be that the brain has reached its limit.”

To understand how exercise affects the brain, the team studied 38 healthy volunteers. Participants exercised on a stationary bicycle, reaching around 85 percent of their predicted maximum heart rate. To measure glutamate and GABA, the researchers conducted a series of imaging studies using a powerful 3-tesla MRI to detect nuclear magnetic resonance spectra, which can identify several compounds based on the magnetic behavior of hydrogen atoms in molecules.

The researchers measured GABA and glutamate levels in two different parts of the brain immediately before and after three vigorous exercise sessions lasting between eight and 20 minutes, and made similar measurements for a control group that did not exercise. Glutamate or GABA levels increased in the participants who exercised, but not among the non-exercisers. Significant increases were found in the visual cortex, which processes visual information, and the anterior cingulate cortex, which helps regulate heart rate, some cognitive functions and emotion. While these gains trailed off over time, there was some evidence of longer-lasting effects.

“There was a correlation between the resting levels of glutamate in the brain and how much people exercised during the preceding week,” Maddock said. “It’s preliminary information, but it’s very encouraging.”

These findings point to the possibility that exercise could be used as an alternative therapy for depression. This could be especially important for patients under age 25, who sometimes have more side effects from selective serotonin reuptake inhibitors (SSRIs), anti-depressant medications that adjust neurotransmitter levels.

For follow-up studies, Maddock and the team hope to test whether a less-intense activity, such as walking, offers similar brain benefits. They would also like to use their exercise-plus-imaging method on a study of patients with depression to determine the types of exercise that offer the greatest benefit.

“We are offering another view on why regular physical activity may be important to prevent or treat depression,” Maddock said. “Not every depressed person who exercises will improve, but many will. It’s possible that we can help identify the patients who would most benefit from an exercise prescription.” Source

Nutrition and Fitness Related Online CE Courses

Physical inactivity is among the most critical public health concerns in America today. For healthcare professionals, the creation and implementation of sustainable fitness solutions is a relevant cause. This course will help you become familiar with the physical and psychological rewards involved in the activity of running, identify risks and the most common running injuries – along with their symptoms and most probable causes – and describe strategies that can be used in preventing running injuries and developing a healthy individualized running regimen.

 

This is a test only course (book not included). The book (or e-book) can be purchased from Amazon. This CE test is based on the book “The Spectrum: A Scientifically Proven Program to Feel Better, Live Longer, Lose Weight, and Gain Health” (2007, 387 pages). Lifestyle changes, including diet, nutrition, exercise, yoga, and meditation, have been proven in research to have multiple beneficial effects on health, including preventing and reversing heart disease, reducing cholesterol, lowering blood pressure, encouraging weight loss, preventing and reversing type 2 diabetes, and preventing and ameliorating cancer. The Spectrum is a research-based lifestyle change program which has been proven effective for multiple health conditions. This course includes a description of the major components (nutrition, stress-management, and exercise) and mechanisms of action. Research on The Spectrum is also described. The book is accompanied by a guide to cooking, 100 easy-to-prepare recipes from award-winning chef Art Smith, and a DVD which provides instruction in meditation. By taking this course, clinicians will learn how to prevent and treat some of the most troubling illnesses of today through lifestyle changes, while avoiding the need for expensive surgery and medication.

 

So often, we think of nutrition and its relationship to our bodies from the neck down. How it affects our heart, how it affects our colon, for example. Why do we not acknowledge its impact on our brain health as well? If a patient were to undergo an elective surgical procedure, he or she may be advised to lose weight, gain weight, or avoid certain medications or herbs beforehand. These recommendations are made to help ensure maximum recovery with minimal complications. Why would we not take this approach when dealing with mental illness as well? Shouldn’t we try to achieve optimal nutritional health of the brain if we are trying to heal it?This course discusses how good nutrition impacts a person’s mental health and well being. Includes discussions on “mental wellness” versus “mental illness,” hypothyroidism and it’s impact on mental health, neurotransmitters and amino acids, glycemic index, vitamins, fatty acids, caffeine, chocolate and aspartame, and herbal supplements and medications. Case studies are provided. This course will give the reader some insight into this concept, by providing the student with clinical research, anecdotal information and a good background for understanding the role nutrition plays in mental health.

 

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This course is a self-instructional module that “walks” readers through the process of replacing their self-defeating weight issues with healthy, positive, and productive life-style behaviors. It moves beyond the “burn more calories than you consume” concept to encompass the emotional aspects of eating and of gaining and losing weight. Through 16 included exercises, you will learn how to identify your self-defeating behaviors (SDBs), analyze and understand them, and then replace them with life-giving actions that lead to permanent behavioral change.* Please note – this course contains common material on eliminating SDBs with Living a Better Life with Chronic Pain: Eliminating Self-Defeating Behaviors

 

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